News

Real-world Study Reveals Side Effects Linked to Cosentyx

Diarrhea, cold-like symptoms, itchy skin, and rash are the most common real-world side effects associated with Cosentyx, an approved treatment for ankylosing spondylitis (AS), a study has found. Such side effects typically emerge in the first month of using the medication, according to the analysis, which included information…

Long-term Brodalumab Treatment for axSpA Supported by Phase 3 Data

Long-term treatment with under-the-skin injections of brodalumab safely and effectively reduced disease activity in people with axial spondyloarthritis (axSpA), according to final data from a Phase 3 trial. axSpA is a type of chronic inflammatory arthritis affecting the joints of the spine, chest, and pelvis. Ankylosing spondylitis (AS) is…

Bimekizumab Now Under Review in Europe for Axial Spondyloarthritis

The European Medicines Agency has agreed to review UCB’s applications seeking the approval of bimekizumab for adults with active axial spondyloarthritis (axSpA). Axial spondyloarthritis is a type of inflammatory arthritis affecting the joints of the spine, chest, and pelvis. Ankylosing spondylitis (AS) is a severe type of axSpA,…

TNF Inhibitor Side Effects Occur at Similar Rates in Rheumatic Diseases

Side effects to anti-TNF therapies are as common and similar among people with ankylosing spondylitis as they are among other rheumatic diseases, a new study indicates. The study, “Disease-specific ADRs of TNF-[alpha] inhibitors as reported by patients with inflammatory rheumatic diseases: a registry-based prospective multicenter cohort study,” was…

AS Led to Rare Ankle, Foot Bone Fusion for Man, 69: Case Study

Ankylosing spondylitis (AS) led to bone formation that resulted in the rare complete fusion of ankle and foot bones in a 69-year-old man, a case study reported. His AS was discovered only after hospitalization for kidney problems and an examination for gout. The researchers suggested the terminology “boot sign”…

Blood Levels of GM-CSF Rise With Disease Activity in AS Patients

High levels of the pro-inflammatory molecule GM-CSF were found in the bloodstream of people with active ankylosing spondylitis (AS) and strongly correlated with disease activity, a pilot study suggested. Despite helping to lower disease activity, anti-TNF therapies did not affect GM-SCF levels. As such, GM-SCF may represent a…