Author Archives: Patricia Inacio PhD

Genes involved in ankylosing spondylitis (AS) as well as potential new therapies have been identified through a computer-based analysis, according to a study. The findings “contribute to our understanding of the molecular mechanisms underlying the onset and progression of AS. They also provide candidate targets for the diagnosis and…

Men with ankylosing spondylitis (AS) are at a higher risk of erectile dysfunction than are healthy men in the general population, according to a meta-analysis of data covering nearly 400 people with AS. “Conflicting results” are evident across the reviewed work, however, and “more high-quality studies are needed in…

The first patient has been randomized in a pivotal Phase 3 program testing oral filgotinib in adults with active axial spondyloarthritis (AxS), including ankylosing spondylitis (AS). The OLINGUITO program (NCT05785611) consists of two placebo-controlled, parallel clinical trials into the safety and efficacy of filgotinib in adults with…

A high concentration formulation of Sandoz’s biosimilar Hyrimoz (adalimumab-adaz) has been approved by the U.S. Food and Drug Administration (FDA) to treat ankylosing spondylitis (AS) and other conditions. The new citrate-free formulation (100 mg/mL) is expected to be available on July 1, according to Sandoz. It’s approved for seven…

People with ankylosing spondylitis (AS) are more likely to develop osteoporosis than the general population, and also seem to develop it earlier in life, according to data from a large medical database in Israel. The risk of the bone condition was particularly higher for women, older patients, and people…

The diagnosis of rare diseases such as akylosing spondylitis (AS) is complex and often delayed. A partnership between U.S. researchers aims to use artificial intelligence to develop a software to diagnose rare diseases sooner. The four-year project, led by researchers at the University of Florida Health and the Perelman School…

Women with axial spondyloarthritis (axSpA) are diagnosed significantly later compared to men, according to a new study. The presence of widespread pain and arthritis were the early symptoms most commonly found in women and linked with a diagnosis delay. The study, “Gender-related differences in axial spondyloarthritis (axSpA)…

People with ankylosing spondylitis (AS)-related kyphosis — a “humpback” appearance — showed good post-surgery outcomes with a technique called satellite rods, a Chinese study shows. The use of satellite rods had been linked to a lower rate of complications in people undergoing spinal surgery, but its use in AS-related kyphosis…

A new and citrate-free formulation of Taltz (ixekizumab) is being made available to treat adults with active ankylosing spondylitis (AS), and non-radiographic axial spondyloarthritis (nr-axSpA) patients who have signs of inflammation. Symptoms of nr-axSpA are similar to AS, but without X-ray evidence of inflammation. This formulation of the Eli Lilly therapy was…

The first healthy volunteer in the U.S. has been dosed in a Phase 1 clinical trial evaluating IMG-004, an oral inhibitor of Bruton’s tyrosine kinase (BTK) being developed as a potential therapy for a wide range of inflammatory and autoimmune diseases, including ankylosing spondylitis (AS). In the Phase 1…