Certain microRNAs, molecules involved in controlling gene activity, were dysregulated in adults with axial spondyloarthritis (axSpA), a study found. Altered levels of these microRNAs were linked with elevated blood levels of pro-inflammatory signaling proteins implicated in the development and activity of axSpA. MicroRNAs as biomarkers “could help improve the early…
Women with ankylosing spondylitis (AS) have a greater risk of pregnancy complications that can affect both the mother and the child than do those without the inflammatory condition, a U.S. population-based study found. Among the maternal complications found were higher rates of cesarean delivery, gestational diabetes, or diabetes during…
The U.S. Food and Drug Administration (FDA) has approved Bimzelx (bimekizumab-bkzx) for adults with active ankylosing spondylitis (AS), UCB Biopharm, the therapy’s developer, has announced. The dual interleukin-17A (IL-17A)/IL-17F inhibitor’s approval also extends to adults with active nonradiographic axial spondyloarthritis (nr-axSpA) with signs of inflammation and active psoriatic…
Changes in the activity of two genes related to a type of programmed cell death called necroptosis — also implicated in other autoimmune diseases — were linked to the development of ankylosing spondylitis (AS), a new study revealed. Those genes, FASLG and TARDBP, were “pinpointed” with the aid of three machine learning…
Genetic analyses found altered activity in several genes related to programmed cell death in ankylosing spondylitis (AS) patients that was not evident in healthy individuals, a study reported. Significantly distinct genetic differences between men and women with AS also were identified, which researchers suggest may serve as new sex-specific…
Treatment with high doses of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of cardiovascular disease among adults with ankylosing spondylitis (AS), according to a Korean real-world study into NSAID dosing. Specifically, the risk was significantly higher for conditions such as heart attack, stroke, and congestive heart…
Opioid use is highly prevalent among people in the U.S. with ankylosing spondylitis (AS), both before and after diagnosis, according to a medical claims database analysis. Similar results also were found among patients with other types of inflammatory diseases affecting the joints, such as psoriatic arthritis and rheumatoid arthritis,…
Changes in the abundance of a bacteria called Escherichia_Shigella within the digestive tract of people with inflammatory bowel disease (IBD) may be related to the development of axial spondyloarthritis (axSpA), a new study revealed. Among the IBD patients, 1 out of every 5 had an axSpA diagnosis, and half lived…
Adults with axial spondyloarthritis (axSpA) remained on golimumab longer than any other TNF inhibitor, according to a real-world analysis of medical records. Although adalimumab (marketed as Humira and biosimilars) was the most commonly prescribed first- and second-line TNF inhibitor, patients stayed with golimumab (marketed…
The decision to escalate treatment for people with highly active axial spondyloarthritis (axSpA) is mainly driven by the physician’s perspective on disease activity, a real-world study has revealed. Further research is needed to better understand these decisions and to optimize axSpA management, according to researchers in the study “…
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