News

Stopping treatment with infliximab (brand names, Remsima, Remicade) can lead to relapses in people with ankylosing spondylitis (AS) who are in stable clinical remission, according to a 12-month study. Reintroduction of infliximab treatment is safe; however, it does not result in the same clinical response prior to treatment withdrawal in a significant…

Despite being rare, kidney complications should be considered in patients with ankylosing spondylitis treated with inhibitors of tumor necrosis factor-alpha (TNF-alpha), such as Remicade (infliximab), according to a case report. The study, “Infliximab-associated focal segmental glomerulosclerosis in a patient with ankylosing spondylitis,” was published in Rheumatology…

While serum levels of sclerostin — a protein that regulates bone formation — are identical in patients with ankylosing spondylitis and healthy individuals, serum BMP-2 levels are higher in patients, suggesting a link between these bone-promoting cells and disease development, a meta-analysis study has found. The study, “Serum Sclerostin…

Treatment with Simponi Aria (golimumab) for one year reduced the signs and symptoms of ankylosing spondylitis (AS) among adult patients with active disease, Phase 3 trial data show. The study, “Safety and efficacy of intravenous golimumab in adults with ankylosing spondylitis: Results through 1 year of the GO-ALIVE…

High levels of the protein chitotriosidase in the blood are associated with more disease activity in ankylosing spondylitis patients. This protein might be a useful prognostic marker. The study, “Serum chitotriosidase and neopterin levels in patients with ankylosing spondylitis,” was published in Therapeutic Advances in Musculoskeletal Disease. Chitotriosidase is…

Gender-based differences in fecal metabolites in ankylosing spondylitis patients may provide clues about differences regarding male versus female disease progression. The study with that finding, “GC-MS-based fecal metabolomics reveals gender-attributed fecal signatures in ankylosing spondylitis,” was published in Scientific Reports. There are a number of differences in how…

A high-fat diet and long-term exposure to air pollution are both associated with worse outcomes in patients with ankylosing spondylitis, a study shows. The study, “Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity,” was published in the journal Advances…

Madeline Collin, a 24-year-old activist with Gaucher disease, worries that patients like her will suffer deeply if Britain leaves the European Union (EU), as scheduled, at the end of this month. Collin is an expert on the subject. For her University of Bathdissertation, she analyzed Brexit’s long-term impact…

Anti-TNF alpha therapy is able to significantly restore ankylosing spondylitis patients’ capacity to exercise after a treatment period of four months, a small study suggests. After treatment, patients in the study improved in objective measures of cardiorespiratory fitness, such as peak oxygen uptake during exercise, maximum work…

High levels of C-reactive protein, a marker of systemic inflammation, at the onset of back pain can help predict which patients go on to develop ankylosing spondylitis, a study shows. The study, “Baseline high-sensitivity C-reactive protein predicts the risk of incident ankylosing spondylitis: Results of a community-based prospective study,”…