News

Two-thirds of adults with spondyloarthritis (SpA), a family of related inflammatory conditions that includes ankylosing spondylitis (AS), reported at least two symptoms related to the gastrointestinal (GI) tract, according to the findings of a new study. About half of SpA patients also reported depression, which significantly correlated with increased disease activity, greater functional…

The Axial Spondyloarthritis International Foundation (ASIF) is encouraging members of the ankylosing spondylitis community to wear orange shoelaces as part of this Saturday’s “Lace Up for axSpA” annual World AS Day. Held each year on the first Saturday of May, the event is designed  to raise awareness…

A version of Purified Cortrophin Gel (repository corticotropin injection) that comes in a prefilled syringe has been approved by the U.S. Food and Drug Administration (FDA) for treating ankylosing spondylitis (AS) and other inflammatory diseases. The injectable treatment from Ani Pharmaceuticals initially was approved in…

The U.S. Food and Drug Administration (FDA) has agreed to review an application seeking approval of AVT05, a proposed biosimilar for Simponi (golimumab), which is an approved treatment for ankylosing spondylitis. Developers Alvotech and Teva Pharmaceuticals said this marks the first time that the FDA has…

Screening is ongoing for adults with active axial spondyloarthritis or axSpA, including ankylosing spondylitis, for a Phase 2 clinical trial in Germany that’s testing sonelokimab — a nanobody in the pipeline of Moonlake Immunotherapeutics for inflammatory diseases of the skin and joints. The goal of the open-label study,…

Levels of multiple immune cell types were found to be altered in the blood of people with ankylosing spondylitis (AS) relative to healthy individuals in a recent study. Immune imbalances correlated with measures of disease severity and, in some cases, a balance was restored over time among patients on…

Most adults with active ankylosing spondylitis or non-radiographic axial spondyloarthritis who achieved low or no disease activity after four months on the recently approved Bimzelx (bimekizumab-bkzx) maintained their clinical response over at least two years. Two-year data from the Phase 3 clinical trials BE MOBILE 1 (NCT03928704)…

People with ankylosing spondylitis (AS) face difficulties in diagnosis and treatment, must deal with the debilitating effects of disease symptoms, and handle adjustments in social roles, often while contending with a lack of understanding and support — all factors that add to an increased disease burden for patients. That’s…

Certain microRNAs, molecules involved in controlling gene activity, were dysregulated in adults with axial spondyloarthritis (axSpA), a study found. Altered levels of these microRNAs were linked with elevated blood levels of pro-inflammatory signaling proteins implicated in the development and activity of axSpA. MicroRNAs as biomarkers “could help improve the early…

Women with ankylosing spondylitis (AS) have a greater risk of pregnancy complications that can affect both the mother and the child than do those without the inflammatory condition, a U.S. population-based study found. Among the maternal complications found were higher rates of cesarean delivery, gestational diabetes, or diabetes during…