A two-week tailored physical therapy program — comprising physiotherapy, occupational therapy, and cognitive behavioral therapy — led to significant improvements in spinal mobility and function among people with axial spondyloarthritis (axSpA), a new study shows. Improvements were assessed using an electronic device, called Epionics SPINE (ES), which objectively evaluates spinal…
The levels of circulating cell-free DNA may be a biomarker for assessing disease activity and treatment response in people with ankylosing spondylitis (AS). The study, “Circulating cell-free DNA correlate to disease activity and treatment response of patients with radiographic axial spondyloarthritis”…
Poor sleep quality is highly prevalent among people with axial spondyloarthritis (axSpA) who have moderate to high disease activity and who don’t practice regular physical exercise, a study from Scandinavia reports. More physical activity and greater cardiorespiratory fitness were associated with better sleep. “The extent and magnitude of reduced sleep…
Uveitis, a form of eye inflammation, and lower socioeconomic status are both linked to a longer time to diagnosis in people with axial spondyloarthritis, known as axSpA, a study reports. In contrast, older age at symptom onset is associated with shorter delays, the researchers noted. “These results suggest that…
Genes involved in ankylosing spondylitis (AS) as well as potential new therapies have been identified through a computer-based analysis, according to a study. The findings “contribute to our understanding of the molecular mechanisms underlying the onset and progression of AS. They also provide candidate targets for the diagnosis and…
Men with ankylosing spondylitis (AS) are at a higher risk of erectile dysfunction than are healthy men in the general population, according to a meta-analysis of data covering nearly 400 people with AS. “Conflicting results” are evident across the reviewed work, however, and “more high-quality studies are needed in…
The first patient has been randomized in a pivotal Phase 3 program testing oral filgotinib in adults with active axial spondyloarthritis (AxS), including ankylosing spondylitis (AS). The OLINGUITO program (NCT05785611) consists of two placebo-controlled, parallel clinical trials into the safety and efficacy of filgotinib in adults with…
A high concentration formulation of Sandoz’s biosimilar Hyrimoz (adalimumab-adaz) has been approved by the U.S. Food and Drug Administration (FDA) to treat ankylosing spondylitis (AS) and other conditions. The new citrate-free formulation (100 mg/mL) is expected to be available on July 1, according to Sandoz. It’s approved for seven…
People with ankylosing spondylitis (AS) are more likely to develop osteoporosis than the general population, and also seem to develop it earlier in life, according to data from a large medical database in Israel. The risk of the bone condition was particularly higher for women, older patients, and people…
The diagnosis of rare diseases such as akylosing spondylitis (AS) is complex and often delayed. A partnership between U.S. researchers aims to use artificial intelligence to develop a software to diagnose rare diseases sooner. The four-year project, led by researchers at the University of Florida Health and the Perelman School…
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