News

Poorer heart and lung function appears to be related to an increased risk of cardiovascular disease in people with ankylosing spondylitis, reported a study that suggested more aerobic exercises might be a way of improving patients’ cardiovascular fitness. The research, “Association between cardiorespiratory fitness and arterial stiffness in ankylosing…

Filgotinib, an investigational therapy for ankylosing spondylitis, was able to significantly reduce disease activity, according to recent Phase 2 study results announced by Gilead Sciences and Galapagos biotech companies. The TORTUGA trial reached its primary efficacy endpoint,…

Patients with ankylosing spondylitis have differences in the diversity of the fungi and bacterial populations that reside in the gut compared with healthy individuals, a study shows. The study, “Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients,” was published in the journal bioRxiv. While the…

Anti-TNF therapy and other biologics — often used for the treatment of inflammatory arthritis — partially protect ankylosing spondylitis patients from heart disease, according to Australian researchers. Their study, “Biologics and cardiovascular events in inflammatory arthritis: a prospective national cohort study,” was published the journal Arthritis Research…

British Columbia is now reimbursing ankylosing spondylitis treatment Renflexis (infliximab-abda) under its public drug plan, according to Merck Canada. Besides adults with ankylosing spondylitis, the reimbursement — effective Aug. 21 — covers all other approved indications. Those include treatment of adult patients with rheumatoid arthritis, psoriatic arthritis…

Izana Bioscience has launched a proof-of-concept Phase 2 clinical study to assess the efficacy of namilumab in patients with moderately to severely active ankylosing spondylitis. The trial is currently recruiting at sites across the U.K., and first results are expected by early 2019. Ankylosing spondylitis is a debilitating type of…

A pilot study will investigate how Cosentyx (secukinumab), which has been approved for some autoimmune disorders, affects bone health in patients with ankylosing spondylitis (AS). The upcoming study — titled “The Effects of Secukinumab on Bone Health and Metabolism” — is currently recruiting and will look at the effects of Cosentyx…

The presence of a gene variant considered to be a risk factor for Crohn’s disease and previously associated with ankylosing spondylitis is independent of bowel inflammation and confers protection against ankylosing spondylitis, a study has found. The study, “Association of Crohn’s disease-related chromosome 1q32 with ankylosing spondylitis…

The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Hulio, a biosimilar to Humira, for the treatment of a number of chronic inflammatory diseases including ankylosing spondylitis. A final decision by the European Commission is expected in October. If approved, the agency would grant marketing authorization…

Inhibiting IL-23, a molecule involved in inflammation, was not found to be clinically meaningful to treat ankylosing spondylitis, according to the results from a Phase 2 trial. The study, “Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study,” was…