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February 24, 2020February 24, 2020

S100A4 Protein Levels May Be Early Biomarker of Axial Spondyloarthritis, Study Suggests

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Blood levels of the protein S100A4 are elevated in patients with axial spondyloarthritis (axSpA), especially at early stages of the disease, a study found. The excessive spinal bone formation ... Read more

February 20, 2020March 3, 2020

Patients, Supporters Worldwide Recognizing Rare Disease Day 2020

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An abundance of events are afoot around the world to mark Rare Disease Day 2020 on Feb. 29. The activities are focused on heightening awareness about rare diseases and ... Read more

February 20, 2020February 20, 2020

TNF Inhibitors During Pregnancy Linked to Greater Risk of Birth Problems, Study Finds

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Women with ankylosing spondylitis (AS) and other inflammatory conditions who take TNF inhibitors during pregnancy may be at higher risk for preterm birth, cesarean section, and smaller babies, according to a ... Read more

February 17, 2020February 17, 2020

New Variant in RELN Gene Linked to AS in Iranian Family

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A new genetic variant in the RELN gene was identified in ankylosing spondylitis (AS) patients in the same family, an Iranian study reports. The study, “Identification of RELN varient p.(Ser2486Gly) ... Read more

February 13, 2020February 13, 2020

Health Canada Approves Taltz for Treatment of Active Ankylosing Spondylitis

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Health Canada approved Taltz (ixekizumab) for the treatment of adults with active ankylosing spondylitis (AS) who have responded poorly to or are unable to tolerate conventional therapies. Eli Lilly‘s ... Read more

February 12, 2020February 12, 2020

FDA Efforts to Bring Patients into Treatment Decisions Focus of NORD Webinar

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The U.S. Food and Drug Administration (FDA), a vast government bureaucracy, employs about 17,500 people and had a budget of $5.7 billion in 2019. Yet even with its enormous ... Read more

February 11, 2020February 11, 2020

Mental Health, Education Among Factors Predicting Lack of Response to TNF-alpha Inhibitors in Axial Spondyloarthritis, Study Says

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Poor mental health, not having a full-time job, spending fewer years in school, and having comorbidities such as hypertension or diabetes all contribute to failure to respond to initial ... Read more

February 7, 2020February 7, 2020

With Post-Brexit Move to Amsterdam Complete, EMA Renews Rare Disease Focus

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The gleaming new Dutch headquarters of the European Medicines Agency (EMA), fronting Domenico Scarlattilaan in Amsterdam’s suburban Zuidas business district, finally opened for business last month — just over ... Read more

February 6, 2020February 6, 2020

Specific Mutations in LTA Gene Determine Risk of Ankylosing Spondylitis, Study Suggests

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Variations in the LTA gene can alter a person’s risk of developing ankylosing spondylitis (AS), a new study suggests. The study, “Associations of lymphotoxin-a (LTA) rs909253 A/G gene polymorphism, plasma level ... Read more

February 3, 2020February 3, 2020

Early Low Blood Levels of Humira and Antibodies Against It Predict Therapy’s Failure, Study Says

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Low levels of Humira (adalimumab) early in the course of treatment and the presence of neutralizing autoantibodies in the blood of people with ankylosing spondylitis (AS) are associated with failure ... Read more

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